Conformational Change Associated with the Acylation of α-Chymotrypsin by N-acetyl-l-phenylalanine Methyl Ester
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منابع مشابه
Conformational properties of N-acetyl-N-methyl-α,β-dehydroalanine N’-methylamide*
The conformational properties of Ac-∆(Me)Ala-NHMe (N-acetyl-N-methyl-α,β-dehydroalanine N’methylamide), as the simplest model of N-methyl-α,β-dehydroamino acids, was examined with theoretical methods and in comparison with Ac-∆Ala-NHMe and Ac-∆Ala-NMe2. The N-terminal amide of the ∆(Me)Ala residue easily adopts the configuration cis and the torsion angles φ, ψ are highly flexible. The ∆(Me)Ala ...
متن کاملThe Pharmacological Activities of the Metabolites of N-[(Trimethylamineboryl)-Carbonyl]-L-Phenylalanine Methyl Ester
The metabolites of N-[(trimethylamineboryl)-carbonyl]-L-phenylalanine methyl ester 1 proved to be active in a number of pharmacological screens where the parent had previously demonstrated potent activity. The proposed metabolites demonstrated significant activity as cytotoxic, hypolipidemic, and anti-inflammatory agents. In cytotoxicity screens several of the proposed metabolites afforded bett...
متن کاملThe hydrolysis of N-benzoyl-DL-tyrosylglycinamide, N-acetyl-L-tyrosylglycinamide, and N-acetyl-DL-tyrosylglycinamide by chymotrypsin.
Contrary to the report of Bergmann and Fruton (1) the L peptide present in aqueous solutions of N-benzoyl-DL-tyrosylglycinamide, prepared by two independent methods, is rapidly hydrolyzed by crystalline chymotrypsin. At 40” and pH 7.8 in a 0.00344 M solution’ of the DL mixture the L component is hydrolyzed as rapidly as in a 0.00172 M solution of the L peptide (Table I). Because of the relative...
متن کاملConformational properties of N-acetyl-L-alanine N',N'-dimethylamide.
Ab initio/DFT analysis of the conformational properties of free Ac-Ala-NMe(2) (N-acetyl-L-alanine-N',N'-dimethylamide) in terms of the N-H.O, N-H.N, C-H.O hydrogen bonds and C(delta+) = O(delta-) dipole attractions was performed. The Ala residue combined with the C-terminal tertiary amide prefers an extended conformation and that characteristic of the (i + 1)th position of the betaVIb turn. The...
متن کاملN-Cinnamoyl-l-phenylalanine methyl ester
As part of an ongoing investigation into the development of N-substituted amino acids as building blocks for dynamic combinatorial chemistry, we report the structure of the title compound, C(19)H(19)NO(3). This compound crystallizes as discrete mol-ecules. The cinnamoyl group is non-planar, with the phenyl ring and the amide twisted out of the ethyl-ene plane. The benzyl and ester groups lie ab...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)42223-0